The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. == Recommendations ==. Amharic), and 8 focus groups (6 English, 2 Spanish) with 69 participants, completed June 2021 to January 2022. Most survey respondents (75%) had heard little or nothing about mAbs, but 95% would consider getting mAb treatment. Hispanic/Latino and Non-Hispanic People of Color (POC) reported less awareness, greater concern about intravenous infusions, and less trust in mAb safety and effectiveness than White, Non-Hispanic respondents. Focus group themes included little awareness but high interest in mAb treatment and concerns about cost and access barriers such as lacking established sources of care and travel from rural communities. Focus groups revealed preferences for broad-reaching but tailored messaging strategies using multiple media and trusted community leaders. Garenoxacin == Conclusions == Despite unfamiliarity with mAb treatment, most respondents were open to receiving mAbs or recommending mAbs to others. While mAb messaging should have broad reach to everyone everywhere, racial and geographic disparities in awareness and trust about mAbs underscore need for tailored messaging to promote equitable access. Care processes should address patient-level barriers like transportation, insurance, or primary care access. COVID-19 treatment dissemination strategies should promote health equity. == Garenoxacin Introduction == For the first year of the COVID-19 global pandemic, little could be done to effectively prevent or treat the disease beyond behavioral steps (e.g., interpersonal distancing) and symptom management. The introduction of neutralizing monoclonal antibody (mAb) treatments represented the first significant evidence-based advancement in outpatient treatment for COVID-19. The first mAb for COVID-19 (bamlanivimab) was authorized for emergency use in the United States in November 2020 to treat symptomatic COVID-19 among high-risk outpatient populations [13]. Additional mAbs were introduced thereafter, and availability and use fluctuated as different mAbs were determined to be more or less effective for different variants [1]. However, despite evidence of effectiveness, a strong recommendation from the National Institutes of Health (NIH), and medication provided free of cost to the patient, widespread use lagged availability and disparities in access and use were observed [4,5]. Even now, as COVID-19 is Cd22 increasingly seen as an endemic condition we must learn to manage [6], there remains a need to ensure timely access to treatment, particularly among racial/ethnic minorities with a disproportionate burden of disease [4,5]. This paper presents a mixed methods analysis of community perspectives on equitable access to mAbs. As with most health care innovations, there are multiple potential factors at the level of individual patients, families, communities, health care and public health systems, and the media that likely influenced uptake of mAbs for treatment of COVID-19 [7]. Presumably central is general community and health care provider awareness of Garenoxacin the existence of evidence-based treatment for COVID-19 among those not yet sick enough to be hospitalized. Implementation factors for accessing care are likely also important. Originally, eligibility was restricted to adults and adolescents with a complex set of criteria indicating a high-risk of poor outcomes for COVID-19 [8]. Initially, treatment required a one-hour intravenous (IV) infusion delivered in a clinical setting with personnel qualified to monitor for adverse reactions [9]. The complex eligibility criteria and IV delivery of treatment requiring care in a well-staffed clinical facility may have contributed to slow uptake and demographic disparities in use [10]. People with symptoms of COVID-19 must be tested, diagnosed, receive a referral for treatment from a medical provider, secure and attend an appointment all within 10 days of first experiencing symptoms and without worsening to the point of requiring hospitalization to receive mAbs. These steps require timely action on the part of people experiencing symptoms of COVID-19 to get tested as well as knowledgeable, prepared health care providers, willing patients, and systems set up to deliver treatment efficiently. Over the course of 2021, eligibility criteria were expanded and simplified, an option for subcutaneous injection was introduced [11], and several states implemented policies designed to facilitate access (e.g., standing orders, self-referral, mobile treatment sites) [1216]. For instance, the state of Colorado set up a secure web-based system to enable community health care providers to refer patients for mAb treatment at one of the multiple infusion sites across the state. Despite efforts to improve access and streamline processes, the multi-step.