In this regard, investigating the epidemiology of the infection among the different segments of population is required to design effective intervention measures. OR with 95% CI was retrieved. P-value of less than 0.05 was considered as statistically significant. Results A total of 208 participants were interviewed. The mean age of respondents was 31.70 (SD 9.123) years. Seroprevalence of contamination was 89 (42.8%). Presence of domestic animals (AOR = 13.33, 95% CI = (2.203C80.692)), sources of drinking water (AOR = 0.011, 95% CI = (0.001C0.110)), toilet type (AOR = 11.236, 95% CI = (1.921C65.73)), shared beds with siblings (AOR PF-5190457 = 7.775, 95% CI = (1.676C36.082)), family size (AOR = 0.015, 95% CI = (0.003, 0.089)), storing and reusing water (AOR =0.014, 95% CI = (0.002C0.103)) and occupational status (AOR = 23.33, 95% CI = (2.034C67.661)) were variables significantly associated with seroprevalence of infection is relatively high in Ethiopia. Family size, shared bed, presences of domestic animals, storage and reuse of water, toilet type, sources of drinking water, and occupation were significant factors associated with contamination. The possible recognized modifiable risk factors should be resolved through effective health education. contamination is usually a global public health problem and PF-5190457 associated with chronic gastritis, and strongly linked to peptic ulcer diseases and gastric malignancy. The bacterium is usually endemic in Africa and Asia. 1 Its prevalence is usually highly variable in relation to geographical area, age, and socioeconomic factors; which is usually high in developing countries. Globally, different strains of appear to be associated with differences in virulence, and the producing interplay with host and environmental factors leads to subsequent differences in the epidemiology of contamination.2,3 It has been well established that is the cause of almost all duodenal ulcers and chronic benign gastric ulcers.4 The infection is found to be associated with gastritis, non-ulcer dyspepsia, duodenal ulcer, gastric ulcer, gastric cancer, and gastric lymphoma of mucosa-associated lymphoid tissue.5 Gastric cancer is a major global health threat and is the third leading cause of cancer deaths worldwide causing an estimated 720,000 deaths per year globally.6,7 Chronic infection can also contribute to gastric mucosal instability by reducing gastric acid secretion.8 An epidemiological survey discloses that infection is significantly higher in developing countries where the prevalence rate ranges between 70% and 90%, as compared to 20C50% in developed countries. The association between contamination and dyspeptic symptoms has long been established with contamination having high populace attributable risk for dyspepsia.9 In Nigeria, various studies on show prevalence rates between 73.0% and 94.5% among patients with dyspepsia10C12. In developing countries, 70C90% of the population harbor is largely through oralCoral or fecal-oral routes. A lack of proper sanitation, safe drinking water, basic hygiene, as well as poor diets and overcrowding, play a role in determining the overall prevalence of contamination. Transmission of the bacterium is usually pronounced through poor environmental sanitation and crowding conditions including fecal contamination of water sources.2,14 In addition, the continuing emergence of resistance to the conventional anti-bacterial drugs used to treat infections is challenging the eradication of in developing countries.15,16 In Ethiopia, studies documented a high prevalence of infection among adults in various localities.17,18 Planning and prevention measures that reduce the general public health impact of infection are critically needed. In this regard, investigating the epidemiology of the contamination among the different segments of populace is required to design effective intervention measures. Hence, the current study was Foxo1 aimed at the assessment of seroprevalence of contamination and associated factors among patients with dyspepsia in selected public health facilities in southwest Ethiopia. Methods Study Design and Setting An institutional-based cross-sectional study was conducted in Mizan Tepi University or college Teaching Hospital (MTUTH) and Mizan health center, Bench Maji Zone, Southwest Ethiopia. The health facilities are located in Southwestern a PF-5190457 part of Ethiopia, Mizan Aman town, 561 km far from the capital city Addis Ababa. The town has a latitude and longitude of 70?N 3535?E/7.000N35.583E, respectively, with an elevation of 1451 meters above sea level. The health facilities are expected to provide medical services for about 1 million people in Southwest Ethiopia and surroundings. The study was conducted from April 1, 2018 to June 30, 2018. Source and Study Populace Adult dyspeptic patients aged 18 years based on ROME III criteria were included in the study. Patients with history of gastrectomy and who were critically ill and unable to give responses were excluded. Sample Size Determination and Process The minimum sample size (n) was determined by using single populace proportion formula [n = (Z /2)2 P (1-P)/d2],.