Hubs are proteins with a large number of interactions in a

Hubs are proteins with a large number of interactions in a protein-protein interaction network. their functional domains. is still disputed. More reliable results were obtained by Higurashi multi-domain architectures. 3 Perspectives The promiscuous nature of proteins has been studied from other perspectives as well. Tsai by mass LAQ824 spectrometry. Nature. 2002;415:180-183. [PubMed] 5 Giot L Bader JS Brouwer C Chaudhuri A Kuang B Li Y Hao YL Ooi CE Godwin B Vitols E Vijayadamodar G Pochart P Machineni H Welsh M Kong Y Zerhusen B Malcolm R Varrone Z Collis A Minto M Burgess S McDaniel L Stimpson E Spriggs F Williams J Neurath K Ioime N Agee M Voss E Furtak K Renzulli R Aanensen N Carrolla S Bickelhaupt E Lazovatsky Y DaSilva A Zhong J Stanyon CA Finley RL Jr White KP Braverman M Jarvie T Gold S Leach M Knight J Shimkets RA McKenna MP Chant J Rothberg JM. A protein interaction map of Drosophila melanogaster. Science. 2003;302:1727-1736. [PubMed] 6 Li S Armstrong CM Bertin N Ge H Milstein S Boxem M Vidalain P-O Han J-DJ Chesneau A Hao T Goldberg DS Li N Martinez M Rual J-F Lamesch P Xu L Tewari M Wong SL Zhang LV Berriz GF Jacotot L Vaglio P Reboul J Hirozane-Kishikawa T Li Q Gabel HW Elewa A Baumgartner B Rose DJ Yu H Bosak S Sequerra R Fraser A Mango SE Saxton WM Strome S van den Heuvel S Piano F Vandenhaute J Sardet C Gerstein M Doucette-Stamm L Gunsalus KC Harper JW Cusick ME Roth FP Hill DE Vidal M. A LAQ824 Map of the interactome network of the metazoan C. elegans. Science. 2004;303:540-543. [PMC free article] [PubMed] 7 Rual JF Venkatesan K Hao T Hirozane-Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi-Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette-Stamm L Cusick ME Hill DE Roth FP Vidal M. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005;437:1173-1178. [PubMed] 8 Stelzl U Worm U Lalowski M Haenig C Brembeck FH Goehler H Stroedicke M Zenkner M Schoenherr A Koeppen S Timm J Mintzlaff S Abraham C Bock N Kietzmann S Goedde A Toksoz E Droege A Krobitsch S Korn B Birchmeier W Lehrach H Wanker EE. A human protein-protein interaction network: A resource for annotating the LAQ824 proteome. Cell. 2005;122:957-968. [PubMed] 9 Gavin A-C Aloy P Grandi P Krause R Boesche M Marzioch M Rau C Jensen LJ Bastuck S Dumpelfeld B Edelmann A Heurtier M-A Hoffman V Hoefert C Klein K Hudak M Michon A-M Schelder M Schirle LAQ824 M Remor M Rudi T Hooper S Bauer A Bouwmeester T Casari G Drewes G Neubauer G Rick JM Kuster B Bork P Russell RB Superti-Furga G. Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006;440:631-636. [PubMed] Rabbit Polyclonal to Adrenergic Receptor alpha-2A. 10 Barabasi AL Oltvai ZN. Network biology: Understanding the cell’s functional organization. Nat. Rev. Genet. 2004;5:101-113. [PubMed] 11 Barabasi AL Albert R. Emergence of scaling in random networks. Science. 1999;286:509-512. [PubMed] 12 Jeong H Mason SP Barabasi AL Oltvai ZN. Lethality and centrality in protein networks. Nature. 2001;411:41-42. [PubMed] 13 Han J-DJ Bertin N Hao T Goldberg DS Berriz GF Zhang LV Dupuy D Walhout AJM Cusick ME Roth FP Vidal M. Evidence for dynamically organized modularity in the yeast protein-protein interaction network. Nature. 2004;430:88-93. [PubMed] 14 Batada NN Reguly T Breitkreutz A Boucher L Breitkreutz BJ Hurst LD Tyers M. Stratus not altocumulus: A new view of the yeast protein interaction network. PLoS Biol. 2006;4:e317. [PMC free article] [PubMed] 15 Bertin N Simonis N Dupuy D Cusick ME Han JD Fraser HB Roth FP Vidal M. Confirmation of organized modularity in the yeast interactome. PLoS Biol. 2007;5:e153. [PMC free article] [PubMed] 16 Batada NN Reguly T Breitkreutz A Boucher L Breitkreutz BJ Hurst LD Tyers M. Still stratus not altocumulus: Further evidence against the date/party hub distinction. PLoS Biol. 2007;5:e154. [PMC free article] [PubMed] 17 Higurashi M Ishida T Kinoshita K. Identification of transient hub proteins and the possible structural basis for their multiple interactions. Protein Sci. 2008;17:72-78. [PMC free.