Study Style: Retrospective cohort review Objectives: Cervical pseudarthrosis is usually a frequent cause of need for revision anterior cervical discectomy and fusion (ACDF) and may lead to worse patient-reported outcomes. regression, PPI use was not found to significantly impact any patient-reported end result measure. However, based on logistic regression, PPI use was found to increase the odds of clinically diagnosed pseudarthrosis (odds ratio 3.552, = .014). Additionally, clinically diagnosed pseudarthrosis negatively influenced improvement in PCS-12 scores (= .022). Conclusions: PPI use was found to be a significant predictor of clinically diagnosed pseudarthrosis following ACDF surgery. Furthermore, clinically diagnosed pseudarthrosis negatively influenced improvement Rabbit Polyclonal to MNT in PCS-12 scores. tests or Mann-Whitney test, depending on normality of the data. Categorical variables were compared using Fishers exact or Pearsons 2 test. A value .05 was considered statistically significant. Results Demographic Data A total of 264 patients were included in our analysis based on inclusion criteria. Overall, there were a total of 206 patients who were not taking a PPI versus 58 sufferers that were going for a PPI ahead of surgery. There have been no baseline variations in demographics except for sex, with the PPI group having a higher proportion of females (64.6% vs 50%, = .036). The average age for those individuals was 53 years, and the mean BMI was 29.6. The mean follow-up was 19.8 months. With regard to period of symptoms preoperatively, 18 (6.8%) experienced less than one month of symptoms, 41 (15.5%) experienced 1 to 3 months, 46 (17.4%) experienced 3 to 6 months, 72 (27.3%) experienced 6 months to 2 years, and 87 (33.0%) experienced 2+ years (= .434). Descriptive statistics for the entire cohort can be found in Table 1. Table 1. Descriptive Characteristics of the Cohort by PPI Use. = .974Sex lover, n (%)= .036*?Male123 (47%)20 (34.5%)103 (50%)?Woman141 (53%)38 (64.6%)103 (50%)BMI, mean [95% CI]29.6 [28.8, 30.3]30.5 [28.9, 32.0]29.3 [28.5, 30.1]= .697Months follow-up, mean [95% CI]19.8 [19.0, 20.6]19.1 [17.4, 20.8]20.0 [19.1, 20.9]= .784Symptom duration, n (%)= .434? 1 Month18 (6.8%)3 (5.2%)15 (7.3%)?1-3 Months41 (15.5%)9 (15.5%)32 (15.5%)?3-6 Weeks46 (17.4%)13 (22.4%)33 (16.0%)?6 Months to 2 years72 (27.3%)11 (19.0%)61 (29.6%)?2 Years+87 (33.0%)22 (37.9%)65 (31.6%)Smoking status, n (%)= .126?Never152 (57.6%)30 (51.7%)122 (59.2%)?Current43 (16.3%)7 (12.1%)36 (17.5%)?Former69 (26.1%)21 (36.2%)48 (23.3%)# Levels fused, n (%)= .158?161 (23%)12 (20.7%)49 (23.8%)?2125 (47%)27 (46.6%)98 (47.6%)?365 (25%)13 (22.4%)52 (25.2%)?412 (5%)5 (8.6%)7 (3.4%)?51 ( 1%)1 (1.7%)0 (0%)Graft type, Dapson n (%)= .493?Allograft243 (92.0%)54 (93.1%)189 (83.6%)?Iliac crest bone graft21 (8.0%)4 (6.9%)17 (16.4%)Analysis, n (%)= .357?Radiculopathy122 (46.2%)22 (37.9%)100 (48.5%)?Myelopathy64 (24.2%)16 (27.6%)48 (23.3%)?Myeloradiculopathy78 (29.6%)20 (44.5%)58 (28.2%) Open in a separate windows Abbreviations: PPI, proton pump inhibitor; CI, confidence interval; BMI, body mass index. *Indicates statistical significance ( .05). Patient-Reported Outcome Measurements Overall, there were no significant variations in end result scores, recovery ratios, or % of individuals Dapson reaching MCID in terms (Table 2). Based on multiple linear regression analysis, PPI use was not found to be a significant predictor for switch in any end result score: NDI (= .578), PCS-12 (= .841), MCS-12 (= .909), VAS Neck (= .654), and VAS Arm (= .762; Table 2). Additional regression analysis revealed that a higher BMI was found to negatively influence NDI score ( = 0.498 [0.103, 0.893], = .014). Length of follow-up was also found to be a significant predictor of changes in NDI ( = Dapson 0.521 [0.142, 0.900], = .007) and VAS Neck ( = 0.081 [0.019, 0.142], = .010). Longer duration of preoperative.